Anti-Aging Interventions

Head of Research Program: Jiří Voller


The team focuses on studying the effects of cytokinins and other phytohormones on various parameters related to aging and age-related diseases. The candidate compounds are evaluated in both human primary cell cultures and Caenorhabditis elegans. The expected indications include neurodegenerative diseases as well as skin aging.  In the fields of dermatology and cosmetics, we are interested in identification of compounds for the treatment of pigmentation disorders (melanogenesis assays) and psoriasis (keratinocyte differentiation assays). We are also developing cytoprotective compounds with the improved skin bioavailability. Bioinformatic and cheminformatic approaches are used to identify both candidate compounds and molecular targets.