Kinase test results (IC50 values in micromoles) from the manuscript Jorda et al. - "How selective are pharmacological inhibitors of cyclin-dependent kinases?" (submitted):
heatcolours: IC50     heat colours: IC50 for each inhibitor scaled to [0,1])     heat colours: logIC50 for each inhibitor scaled to [0,1])

Return to CDKiDB database
CDK1/B CDK2/E CDK2/A CDK4/D1 CDK5/p25 CDK7/H CDK9/T
Dinaciclib 0.072 0.0034 0.0039 0.11 0.045 0.17 0.18
R-CR8 0.79 0.036 0.14 10 0.68 1.8 0.99
JNJ7706621 0.02 0.0018 0.0018 0.56 0.017 1.2 0.061
SNS032 0.2 0.0045 0.023 0.45 0.44 0.29 0.048
Flavopiridol 0.49 0.23 0.084 0.21 0.26 0.82 0.025
CDK2/9 inhibitor 0.15 0.01 0.01 0.66 0.19 0.17 0.051
BML259 1.7 0.2 0.35 10 0.46 0.64 3.4
BIO 0.27 0.014 0.069 0.53 0.041 3.5 0.45
PNU112455A 5.3 1.9 0.95 10 4.4 10 10
(R)-DRF053 3.7 0.093 0.29 10 0.21 0.82 8
CDK1/5 inhibitor 9.7 5.6 4.4 10 10 10 10
CDK1/2 inhibitor III 0.0021 0.0028 0.0002 0.059 0.0002 0.066 0.03
BMS265246 0.014 0.0056 0.071 0.22 0.26 1.6 1.8
NU6102 0.15 0.022 0.014 0.18 0.12 2.5 4.1
CGP60474 0.026 0.003 0.0041 0.22 0.0095 0.2 0.013
CDK9-IN-2 0.55 0.15 0.17 1.8 1.1 2.3 0.033
LDC000067 4 2.3 1.1 3.2 5 10 0.23
CDK-IN-2 0.22 0.86 0.32 0.63 7.3 4.9 0.05
PHA767491 1.1 1.2 0.64 10 1 10 0.076
BS181 10 1.4 1.3 10 4.3 0.11 1.8
Ribociclib 10 10 10 0.03 10 10 3.9
ON123300 0.6 0.38 0.055 0.018 0.27 6 0.12
Abemaciclib 0.37 0.35 0.046 0.0052 0.4 3.1 0.1
CDK4 inhibitor V 0.29 0.5 0.071 0.038 1.2 10 1
Palbociclib 9.8 9.1 1.8 0.013 10 10 1.1
CDK4 inhibitor 1.5 0.23 0.19 0.091 0.15 10 4
Arcyriaflavin A 0.96 0.53 0.14 3.1 0.94 10 10
CINK4 9.2 5.2 10 10 10 10 10
Ryuvidine 10 10 10 9.5 10 10 10
NSC625987 10 10 10 10 10 10 10
Milciclib 1.2 0.59 0.11 0.22 0.38 0.27 7.7
NU6140 5.5 1.2 0.41 0.94 8.8 2.3 5.1
SU9516 0.17 0.026 0.027 1.7 0.022 0.9 1.5
CDK2 inhibitor II 1.3 0.031 0.041 2.8 0.74 10 1.1
GW8510 0.049 0.0028 0.0033 0.14 0.0067 0.32 0.54
CVT313 3.7 0.18 0.22 10 0.42 9.2 2.3
RO3306 0.047 0.19 0.25 10 2.5 10 10
Elbfluorene 10 10 10 10 10 10 10
Benfluorene 10 10 7.1 10 10 10 10
CDK1 inhibitor 6.7 9.4 10 10 5.8 10 10
CGP74514A 0.15 0.026 0.046 3 0.026 0.28 1.4